Santa Diabla is the story of Santa Martínez, a woman who seeks revenge for the murder of her husband Willy Delgado.

An engineer who works in a large construction company and a poor worker without aspirations both share a love that dared to go beyond all prejudices and differences.

A woman's refusal to join her sister's twisted scheme sparks betrayal and revenge as she tries to reunite with her long-lost daughter in prison.